The misuse of scientific advancements as deadly or devastating weaponry is an ongoing fear, initially realized in World War I. The use of poisonous gases at that time resulted in the establishment of the 1925 Geneva Protocol, which ban asphyxiating, poisonous or other gases and bacteriological methods of warfare. Subsequent international law developments include the 1972 Biological and Toxin Weapons Convention, strengthening the 1925 Protocol and mandating national legislation further prohibiting the proliferation and retention of such weapons, along with the 1993 Chemical Weapons Convention which did much the same for these weapons. These Conventions do not seek to interfere with scientific development; rather, they provide keen monitoring mechanisms to prevent misappropriation.